Price : USD 14
Kshaya, Dourbalya, (General debility)
Vataroga (Neurological diseases) Klaibya
(Impotency) and as Rasayana. (anti oxidant)
2 capsule thrice a day or as per the
direction of physician
Ashwagandha is used as a general tonic and "adaptogen",
helping the body adapt to stress. There is an herb
regarded as a 1st class adaptogenic tonic in one of the
world's greatest herbal medical systems.
Ashwagandha is one of the most widespread tranquillizers
used in India.
Ashwagandha is also useful for strengthening the female
reproductive system. It potentate reproductive hormones.
Ashwagandha has been shown to possess antioxidant
activity as well as an ability to support a healthy
immune system. It has the ability to increase vitality,
energy, endurance and stamina, promote longevity and
strengthen the immune system without stimulating the
body's reserves. It has the ability to nurture the
nervous system, counteract anxiety and stress to promote
a calm state of mind.
Ashwagandha is also anti-inflammatory, anti-arthritic,
anti-anxiety calmative, aphrodisiac, and sedative and as
an overall rejuvenate.
Because the primary quality and flavor of Ashwagandha is
sharp and pungent, it helps in raising metabolism,
stimulates digestion, clears mucus, and improves
circulation. It is used as a Kidney tonic because of its
warming, aphrodisiac properties. It is used for tumors,
inflammation (including arthritis), and a wide range of
The bitter leaves are used as a hypnotic in the
treatment of alcoholism and to relax the spasms of the
lungs for the treatment of asthma and emphysema.
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Ayurveda, W. somnifera is regarded as one of the most
useful herbs having �Vata� pacifying properties (Sangwan
et al., 2004; Singh and Kumar, 1998). Dried roots are
the source of drug and have got a vast range of
application in the treatment of different physiological
disorders. The drug also holds a great promise as an
adjuvant in radiation therapy treatment of cancer. The
drug is classified under the group Rasayana' in Ayurveda
which besides other properties, also checks aging.
Ashwagandha twigs are chewed for cleaning teeth, and the
smoke of the plant is inhaled for relief in toothache.
It is also used as a febrifuge.
The roots and paste of green leaves are used to relieve
joint pain and inflammation. It is highly recommended
medicament for curing disability and sexual weakness in
the male. Seeds are diuretic. The leaves are bitter and
given in fever. They are bruised and applied to lesions,
painful swellings, and sore eyes. A paste made from the
leaves is prescribed for syphilitic sores.
Its roots were prescribed for hiccup, female disorders,
cough, rheumatism and dropsy, and as a sedative in cases
of senile debility. It is a folk remedy for many
diseases. Its roots are prescribed in medicines for
hiccup, cough, dropsy, rheumatism, senile debility,
ulcer and scabies. Internally, it is used to tone the
uterus after miscarriage and treatment of post-partum
difficulties. Externally, it is applied as a poultice to
boils, swellings and other painful body parts.
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Roots show antitumour and
radiosensitizing effects in animal models. Total
alkaloid fraction of the root extract exhibits
hypotensive, bradicardiac and respiratory stimulant
activities in dogs. It shows relaxant and antispasmodic
effects against several plasmogens on intestinal,
uterine, bronchial, tracheal and blood vessel muscles.
Withanolides possess remarkable antibacterial,
antitumour, antiarthritic and immunosuppressive
properties and protective effect against carbon
tetrachloride induced hepato-toxicity. Withaferin A
shows marked tumour-inhibitory activity when tested in
vitro against cells derived from human carcinoma of
nasopharynx (KB). It also acted as a mitotic poison
arresting the division of cultured human larynx
carcinoma cells at metaphase and in HeLa cultures
similar to star -metaphase. It also produced significant
retardation of the growth of Ehrlich ascites carcinoma,
Sarcoma 180, Sarcoma Black (SBL), and E 0771 mammary
adenocarcinoma in mice in doses of 10, 12, 15 mg./kg.
body-wt. Growth of Ehrlich ascites carcinoma was
completely inhibited in more than half the mice which
survived for 100 days without the evidence of growth of
the tumour. Withaferin A caused mitotic arrest in
embryonal chicken fibroblast cells. Methylthiodeacetyl
colchicine potentiated the effect of withaferin A.
The total alkaloids of roots have a variety of
pharmacological actions. They exhibited prolonged
hypotensive, bradycardiac, and respiratory -stimulating
action in dogs. The hypotensive effect is due mainly to
autonomic ganglion-blocking action. The depressant
action on the higher cerebral centres also contributes
to the hypotension. The total alkaloids produced a
taming and a mild depressant effect
(tranquillizer-sedative type) on the central nervous
system in several experimental animals. The
neuro-pharmacological activity was accredited to the
acetone-soluble fraction of the total alkaloids. In
another experiment, the depressive effect was attributed
to the basic alkaloids in the roots, the neutral
alkaloids (3-tropyltigloate and an unidentified
alkaloid) showing no depressive effect on spontaneous
The total alkaloids showed relaxant and antispasmodic
effects against several spasmogens on intestinal,
uterine, bronchial, tracheal and blood-vascular muscles.
The pattern of smooth muscle activity of the alkaloids
was similar to that of papaverine which suggested a
direct musculotropic action; both as relaxant and
spasmolytic, the alkaloids are, however, much weaker
than papaverine. This pharmacological activity lends
credence to the use of aswagandha in asthma and as a
uterine sedative in the Ayurvedic system of medicine.
Ashwagandha is classified as tranquilizer, adaptogenic
and antiinflammatory. It is found to decrease the degree
of anxiety and depression and can be used as
antidepresent. The effect of extract of the drug on
mouse central nervous system has demonstrated a
significant increase of the narcosis time. The recovery
of righting reflex was sex and dose dependent. Alongwith
Panax ginseng and Tribulus terrestris, ashwagandha was
found to give improvement over all psychomotor functions
including adaptability of patients, to various stresses
and in the building of tissues. The methanolic extract
of the drug inhibited the specific binding of GABA
showing GABA recepter mediated anticonvulsent activity
Withaferin A exhibits fairly potent anti-arthritic and
anti-inflammatory activities. It was found to suppress
arthritic syndrome without any toxic effect. Unlike
hydrocortisone-treated animals which lost weight, the
animals treated with withaferin A showed gain in weight
in arthritic syndrome. It is interesting that withaferin
A seems to be more potent than hydrocortisone in
adjuvant-induced arthritis in rats, a close experimental
approximation to human rheumatoid arthritis. In its
oedema-inhibiting activity, the compound gave a good
dose-response in the dose-range of 12-25 mg./kg.
body-wt. of albino rats intraperitoneally and a single
dose had a good duration of action, as it could
effectively suppress the inflammation after four hours
of its administration.
Extract of ashwagandha induced significant decrease in
the arterial and diastolic blood pressure in
normotensive pentobarbital anaesthetized dogs. It also
prevented the hypotensive effect of acetylcholine and
increased the hypertensive effect of adrenaline.
Alcoholic extract of the drug produced good response
against mouse tumor, Sarcoma 180. In combination with
gamma-radiation and hyperthermia treatment, ashwagandha
significantly increased the tumor cure, growth delay of
partially responding tumors and animal survival.
Ashwangandha, in addition to having inhibitory effect,
also acts as radio sensitizer and heat enhancer.
Ashwagandha produces good sedation and proved to be a
better drug in allaying apprehension than promethazine.
It is helpful in producing smooth sleep induction with
significantly shorter induction period. It does not
produce any cardiovascular and respiratory depressant
effect in preanaesthetic period, during the course of
subsequent anaesthesia and in recovery period. In
Ayurvedic medicine, Withania somnifera (Ashwagandha) is
well known for its anti-stress activity.
Ashwagandha alters the concentration of
Neurotransmitters - Chemical substances that are known
to play an important role in Brain Processes such as
Memory. An abnormally high level of Gamma Amino Butyric
Acid (GABA) or a reduction in the level of
Acetylcholine, both Neurotransmitters can affect Memory.
The roots contain Fe (0.218), K (1.87), Mg (0.19) and Ni
(0.126 mg/gm of dry plant material), along with other
elements, which are reported to play a significant role
in the diuretic and aphrodisiac activity of the drug.
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Hypoglycemic, diuretic and hypocholesterolemic effects
of roots of W. somnifera (ashwagandha) were assessed on
human subjects. Six mild NIDDM and six mild
hypercholesterolemic subjects were treated with the root
powder of W. somnifera for 30 days. Suitable parameters
were studied in the blood and urine samples. Significant
increase in urine volume, sodium in the urine;
significant decrease in serum cholesterol,
triglycerides, LDL (low density lipoproteins) and VLDL
(very low density lipoproteins) cholesterol were
observed indicating the root of ashwagandha to be a
potential source of hypoglycemic, diuretic and
hypocholesterolemic agents (Andallu and Radhika 2000).
The alcoholic extract of the dried roots of the plant as
well as the active component withaferin A isolated from
the extract showed significant antitumour and
radiosensitizing effects in experimental tumours in
vivo, without any noticeable systemic toxicity. Further
studies are needed to explore the clinical potential of
this plant for cancer therapy (Devi 1996).
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toxicity seen after 90 days of ginseng and ashwagandha
to rats (Aphale 1998). Acute LD50 for withaferin A in
Swiss mice is around 80 mg/kg (Sharad 1996).
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somnifera is contraindicated during pregnancy unless
under the direction of a qualified medical doctor. Large
doses may possess abortifacient properties. It is also
contraindicated in conjunction with sedatives such as
barbiturates or anxioletics or in cases of stomach
ulcer. Berriers may cause severe gastrointestinal pain,
should not be eaten.
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Abbas,M.,Tomar S.S.,Nigam,K.B.,1994. Effect of plant
density and cultivars of Ashwagandha (Withania somnifera
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Response of Withania somnifera Dunal leaf explants
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Abraham, A., I. Kirson, E. Glotter and D. Lavie.1968. A chemotaxonomic study of
Withania somnifera (L) Dunal . Phytochemistry, 7: 957-62.
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Al-Hindawi, M.K., Al-Khafaji S.H., Abdul-Nabi, M.H., 1992. Anti-granuloma
activity of Iraqi Withania somnifera. J Ethnopharmacol. 37(2):113-6.
Ali, M., Shuaib, M., and Ansari, S.H., 1997. Withanolides from the stem bark of
Withania somnifera. Phytochemistry, 44(6): 1163-68.
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Abdel-Magied, E.M., 2000.The effect of extracts of Cynomorium coccineum and
Withania somnifera on gonadotrophins and ovarian follicles of immature Wistar
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Anabalagan, K., Sadiques,J., 1981.Influence of Indian Medicine (Ashwagandha) on
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Anjaneyulu, A.S.R., and S.D. Rao., 1997. New with anolides from the roots of
Withania somnifera. Indian Journal of Chemistry; 36.,B; 161-65
Aphale, A.A., Chhibba, A.D., Kumbhakarna, N.R., Mateenuddin, M., and Dahat,
S.H.,1998. Subacute toxicity study of the combination of ginseng (Panax ginseng)
and ashwagandha (Withania somnifera) in rats: a safety assessment. Indian J
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Archana, R., Namasivayam, A., 1999. Anti stress effect of Withania somnifera. J
Ariz,P., Iftikhan,N., and Khan,N.R.,1972. The megasporogenesis and the
development of embryo sac in Withania somnifera. Pakistan Jour.Sci.Ind. Res.
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Aschar, K.R.S., Schmulterer, H., Glotter E., Kirson,I., 1984 Distribution of the
chemotypes of W. somnifiera in some areas of Israel Feeding studies with
Spodoptera littoralis larvae and chemical examination of Withanolide content.
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5,20-a(r)dihydroxy-6a,7a,epoxy-1-oxo-5a,with2,2g,dienolide and solasodine.
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Banerjee, S., Naqvi, A.A., Mandal, S., and Ahuja. P.S., 1994. Transformation of
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Begum, V.H., Sadique J.1988. Long term effect of herbal drug Withania somnifera
on adjuvant induced arthritis in rats. Indian J. Exp Biol. 26(11):877-82.
Begum, V.H., Sadique, J. 1987. Effect of Withania somnifera on glycos amino-
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Bessele R., Lavie D., Frolow F.,1987. Withanaloid Y, a withanaloid from a hybrid
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Besselle R., Lavie D. 1987. Semiquantitative reverse phase high performance
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115-19. Malhotra Publishing House, New Delhi, India.
Bhattacharya, S.K, Satyan, K.S., Chakrabarti A., 1997. Effect of Transina, an
Ayurvedic herbal formulation, on pancreatic islet superoxide dismutase activity
in hyperglycaemic rats. Indian J Exp Biol. 35(3):297-9.
Bhattacharya, S.K. 1998. Adaptogenic activity of siotone, a herbal formulation
against an unpredictable chronic stress induced physiological and behavioral
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Medicinal Plant Research, Calcutta, 2-4 April, 1998.
Bhattacharya, S.K., A. Kumar and S. Ghosal. 1995. Effects of glycowithanolides
from Withania somnifera on an animal model of Alzheimer's disease and perturbed
central cholinergic markers of cognition in rats. Phytotherapy Research, 9:
Bhattacharya, S.K., Goel, R.K., Kaur, R., and Ghoshal, S., 1987. Anti-stress
activity of sitoindosides VII and VIII, New acylsterylglycosides from
W.somnifera. Phytother Res. 1, 32-37.
Bhattacharya, S.K., Satyam Kulkunte, S., and Ghosal, Shibnath., 1997.
Antioxidant activity of glycowithanolides from W somnifera in rat brain frontal
cortex and striatum. Indian J. Experimental Biology, 35, 236-239.
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glycowithanolides from Withania somnifera. Indian J Exp Biol. 35(3):236-9.
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Bioactive peptide fraction from the plant W.somnifera. Indian Patent
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